Group Sequential Survival Trial Design and Monitoring Using the Log-Rank Test
نویسندگان
چکیده
منابع مشابه
Crossing survival curves: alternatives to the log-rank test
Background It is not uncommon for clinical trials to present results on survival time as Kaplan-Meier survival curves that cross, indicating non-proportional hazards. A recent example was given in a pivotal trial in advanced nonsmall cell lung cancer (The ‘IPASS study’ [1]). Trials such as these present a hazard ratio and log-rank test for treatment comparison as this is their planned primary a...
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ژورنال
عنوان ژورنال: Statistics in Biopharmaceutical Research
سال: 2017
ISSN: 1946-6315
DOI: 10.1080/19466315.2016.1189355